Trifluoroacetic acid → HCID 58903145, compound

HRID 273410Notes

Reaction equation

HRID 273410 reaction equation
[CH2:1]([S:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[C:13]([CH3:15])[C:12]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][O:23][C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])=[CH:26][CH:25]=3)[CH:17]=2)=[C:11]([CH3:39])[CH:10]=1)(=[O:5])=[O:4])[CH3:2].FC(F)(F)C(O)=O>C1(C)C=CC=CC=1>[CH2:1]([S:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[C:13]([CH3:15])[C:12]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][O:23][C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[CH:26][CH:25]=3)[CH:17]=2)=[C:11]([CH3:39])[CH:10]=1)(=[O:5])=[O:4])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58903179HCID 58903179, compound

Product 1

HCID 58903145HCID 58903145, compoundYield 72.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of tert-butyl 3-[4-({4′-[2-(ethylsulfonyl)ethoxy]-2′,6′-dimethylbiphenyl-3-yl}methoxy)phenyl]propanoate (0.37 g, 0.67 mmol) in toluene (3.7 mL) was added trifluoroacetic acid (3.7 mL) at room temperature with stirring and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was concentrated under reduced pressure, the obtained crystals were collected by filtration, washed and dried to give the title compound (0.24 g, yield 72%) as colorless crystals.

Workup

  1. stirringthe mixture was stirred at room temperature for 2 hrs
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. filtrationthe obtained crystals were collected by filtration
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-97eed43bc92d487fa398a8904d4361cf
Source dataset
uspto-grants-2008_11
Patent number
US07456218B2

Reaction notes

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