Benzyl Bromide → 2-benzylthiobenzimidazole

HRID 273757Notes

Reaction equation

HRID 273757 reaction equation
[SH:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH2:11](Br)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(O)C>[CH2:11]([S:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 178527775HCID 178527775, compound

Product 1

HCID 4167702-benzylthiobenzimidazoleYield 77.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

15 g of 2-mercaptobenzimidazole and 16.5 g of benzylbromide were dissolved in 50 ml of ethanol and the mixture was refluxed with a water bath for 5 hours. After cooling, the formed crystals were collected and recrystallized from ethanol to obtain 18 g of compound (7).

Workup

  1. temperaturethe mixture was refluxed with a water bath for 5 hours
  2. temperatureAfter cooling
  3. customthe formed crystals were collected
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-7175b79b224f4cfa82d7a772c722a4a5
Source dataset
uspto-grants-1995_02
Patent number
US05387600

Reaction notes

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