Ammonia → HCID 178507484, compound

HRID 273786Notes

Reaction equation

HRID 273786 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](O)=[CH:3][CH:2]=1.O.[NH2:13][NH2:14].N>Cl>[NH:13]1[CH:2]=[CH:3][C:4]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:10]=2[NH2:1])=[N:14]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 24654Hydrazine hydrate (1:1)HCID 178516385quinolin-4-ol

Product 1

HCID 178507484HCID 178507484, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

1.1. 10.0 g of 4-quinolinol in 30g of hydrazine hydrate are heated to 170° C. in an autoclave for 6 h. After cooling, the reaction mixture is dissolved in aqueous hydrochloric acid (total volume of the solution about 300 ml, pH about 1). Then, the mixture is made slightly alkaline (pH about 9) with concentrated aqueous ammonia solution. The separated crystals are filtered off and dried. There are obtained 8.0 g of 2-(1H-pyrazol-3-yl)aniline of m.p. 122°-123° C.

Workup

  1. temperatureAfter cooling
  2. filtrationThe separated crystals are filtered off
  3. customdried

Sources & evidence

ORD record
ord-112008c3b4ed402fb72885bbfe4d3205
Source dataset
uspto-grants-1995_02
Patent number
US05387585

Reaction notes

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