Water → HCID 178442091, compound

HRID 274163Notes

Reaction equation

HRID 274163 reaction equation
CC(C[AlH]CC(C)C)C.[C:10]([C@H:12]1[CH2:17][CH2:16][C@H:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)[CH2:14][CH2:13]1)#N.O.S(=O)(=O)(O)[OH:37]>CCCCCC.CCCCC>[CH:10]([C@H:12]1[CH2:17][CH2:16][C@H:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)[CH2:14][CH2:13]1)=[O:37]

Participants

7

Reactant 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 14487Diisobutylaluminum hydrideHCID 178442090HCID 178442090, compound

Product 1

HCID 178442091HCID 178442091, compound

Reagents, catalysts & solvents 2

HCID 8003PentaneSolventHCID 8058HexaneSolvent

Procedure

112 ml of a 20% solution of DIBALH in hexane are added dropwise to a solution of 33.2 g of 4-(trans-4-cyanocyclohexyl)-4'-pentylbiphenyl in 1 l of pentane, and the mixture is stirred for 18 hours. Water is then added dropwise until the evolution of gas subsides and then 200 ml of 25% sulfuric acid are added dropwise. The organic phase is separated off, dried over Na2SO4 and evaporated. Colourless deliquescent crystals are obtained.

Workup

  1. customThe organic phase is separated off
  2. dry with materialdried over Na2SO4
  3. customevaporated
  4. customColourless deliquescent crystals are obtained

Sources & evidence

ORD record
ord-eb5dc1724d7848e3850b97b42f2dc97f
Source dataset
uspto-grants-1995_02
Patent number
US05389292

Reaction notes

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