Hydrochloric Acid → HCID 18927875, compound

HRID 274173Notes

Reaction equation

HRID 274173 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH:18]([O:20][CH2:21][CH2:22][CH3:23])[CH3:19])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)(=O)C.[OH-].[Na+].Cl.C(OCC)(=O)C>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:16]=[CH:15][C:14]([CH2:17][CH:18]([O:20][CH2:21][CH2:22][CH3:23])[CH3:19])=[CH:13][CH:12]=2)=[CH:9][CH:10]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 18927863HCID 18927863, compound

Product 1

HCID 18927875HCID 18927875, compoundYield 101.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Then, 2.5 g (8 mM) of the thus-obtained (-)-4-acetoxy-4'-(2-propoxypropyl)biphenyl was dissolved in 30 ml of methanol, added with 20% NaOH aqueous solution, and sturred at room temperature for 2 hrs. After completion of the reaction, the reaction solution was added with 1N hydrochloric acid till pH 2-3, and then further added with 100 ml of ethyl acetate to subject extraction treatment. The resulting organic layer was water-washed and then concentrated under a reduced pressure to obtain 2.2 g of (-)-4-hydroxy-4'-(2-propoxypropyl)biphenyl (V-43) with 100% yield.

Workup

  1. customAfter completion of the reaction
  2. extractionextraction treatment
  3. washwashed
  4. concentrationconcentrated under a reduced pressure

Sources & evidence

ORD record
ord-4e4c896358444a48879114c2aed2a112
Source dataset
uspto-grants-1995_02
Patent number
US05389293

Reaction notes

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