2-Fluoro-6-phenylsulfonylpyridine → HCID 17911500, compound

HRID 274184Notes

Reaction equation

HRID 274184 reaction equation
[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([Mg]Br)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[F:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21](S(C2C=CC=CC=2)(=O)=O)[N:20]=1>C1COCC1>[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([F:18])[N:20]=2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

4

Reactant 2

HCID 200921242-Fluoro-6-phenylsulfonylpyridineHCID 178443728HCID 178443728, compound

Product 1

HCID 17911500HCID 17911500, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A mixture of 0.06 mol of 4-octyloxyphenylmagnesium bromide (prepared from 0.06 mol of 4-octyloxybromobenzene and 0.06 mol of 4-octyloxybromobenzene and 0.06 mol of magnesium) and 25 ml of THF is added at 30°-40° C. to a mixture of 0.05 mol of 2A and 15 ml of THF. The mixture is stirred at room temperature for 2 hours and subjected to customary work-up. The unpurified product is processed further in accordance with 2C.

Sources & evidence

ORD record
ord-0ebe7af01dd1422d94d9b09a62629736
Source dataset
uspto-grants-1995_02
Patent number
US05389291

Reaction notes

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