Hydrochloric Acid → 4-[(4-Cyanophenyl)methylene]-2,5-dioxo-1-imidazolidineacetic acid

HRID 274226Notes

Reaction equation

HRID 274226 reaction equation
[C:1]([C:3]1[CH:27]=[CH:26][C:6]([CH:7]=[C:8]2[NH:12][C:11](=[O:13])[N:10]([CH2:14][C:15]([O:17]CC3C=CC=CC=3)=[O:16])[C:9]2=[O:25])=[CH:5][CH:4]=1)#[N:2].Cl>C(O)(=O)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH:7]=[C:8]2[NH:12][C:11](=[O:13])[N:10]([CH2:14][C:15]([OH:17])=[O:16])[C:9]2=[O:25])=[CH:26][CH:27]=1)#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53926892HCID 53926892, compound

Product 1

HCID 544096794-[(4-Cyanophenyl)methylene]-2,5-dioxo-1-imidazolidineacetic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

0.4 g (1.1 mmol) of benzyl (5-(4-cyanobenzylidene)-2,4-dioxoimidazolidin-3-yl)-acetate are heated under reflux with 5 ml of 6N HCl and 5 ml of acetic acid for 30 minutes, the mixture is filtered hot and the filtrate is cooled. The product which has precipitated is filtered off with suction, washed with water and dried.

Workup

  1. filtrationthe mixture is filtered hot
  2. temperaturethe filtrate is cooled
  3. customThe product which has precipitated
  4. filtrationis filtered off with suction
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-9f7e358b7449475c9669d89d661311f6
Source dataset
uspto-grants-1995_02
Patent number
US05389614

Reaction notes

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