1-Methylpiperazine → 3-(1-Methyl-4-piperazinylsulfonyl)-1-propanol

HRID 274298Notes

Reaction equation

C([O:4][CH2:5][CH2:6][CH2:7][S:8](Cl)(=[O:10])=[O:9])(=O)C.[CH3:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[CH3:12][N:13]1[CH2:18][CH2:17][N:16]([S:8]([CH2:7][CH2:6][CH2:5][OH:4])(=[O:9])=[O:10])[CH2:15][CH2:14]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 105842113-(Chlorosulfonyl)propyl acetate

Product 1

HCID 152348893-(1-Methyl-4-piperazinylsulfonyl)-1-propanol

Procedure

Using 3-acetoxypropane-1-sulfonyl chloride and 1-methylpiperazine, the same reaction as in Reference Example 44 and 46 was conducted to produce the title compound. m.p. 90°-93° C.

Workup

customthe same reaction as in Reference Example 44 and 46

Sources & evidence

ORD record: ord-8ae26d1d66354be29ec0dbb0f6315e72
Source dataset: uspto-grants-1995_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05389633

Reaction notes

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