反应详情

温度

100 °C

86.0 g (0.3 mol) of phosphorus oxybromide was added to 73.1 g (1.0 mol) of N,N-dimethylformamide, and 15.1 g (0.1 mol)of guanine (manufactured by Sumika Fine Chemicals Co., Ltd.) was then added, followed by stirring at 100° C. for 4 hours. After cooling, 200 ml of water was carefully added at 20° C. After stirring at room temperature for 24 hours, the precipitating crystal was collected by filtration and dissolved in 200 ml of 25% aqueous ammonia with heating, and the insoluble substances were filtered out. The mother liquor was concentrated under reduced pressure, and the precipitating crystal was collected by filtration to yield 11.1 g (0.052 mol) of a pale yellow crystal of 2-amino-6-bromopurine (yield 52%). Its properties are as follows:

1. additionwas then added
2. temperatureAfter cooling
3. stirringAfter stirring at room temperature for 24 hours
4. filtrationthe precipitating crystal was collected by filtration
5. dissolutiondissolved in 200 ml of 25% aqueous ammonia
6. temperaturewith heating
7. filtrationthe insoluble substances were filtered out
8. concentrationThe mother liquor was concentrated under reduced pressure
9. filtrationthe precipitating crystal was collected by filtration