Acetyl chloride → HCID 23342828, compound

HRID 27433Notes

Reaction equation

HRID 27433 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][C:6]1[CH:20]=[CH:19][C:9]([CH2:10][CH:11]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][N:12]2[CH3:18])=[CH:8][CH:7]=1.C(N(CC)CC)C>C1C=CC=CC=1>[C:1]([NH:5][C:6]1[CH:20]=[CH:19][C:9]([CH2:10][CH:11]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][N:12]2[CH3:18])=[CH:8][CH:7]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 23342841HCID 23342841, compound

Product 1

HCID 23342828HCID 23342828, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

Add a solution of 0.75 g of acetyl chloride in 5 ml of benzene drop by drop to a solution of 1.9 g of the title compound of Example 22 and 1 g of triethylamine in 10 ml of benzene. After an hour concentrate the resulting product, take it up with water and diethyl ether, collect the organic phase and concentrate it to obtain the title compound.

Workup

  1. concentrationAfter an hour concentrate the resulting product
  2. customcollect the organic phase
  3. concentrationconcentrate it

Sources & evidence

ORD record
ord-8cbc41c33a6a472cadf7e50e719973b3
Source dataset
uspto-grants-1980_09
Patent number
US04221788

Reaction notes

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