Sodium hydride → HCID 15239111, compound

HRID 274356Notes

Reaction equation

HRID 274356 reaction equation
[CH3:1][CH:2]([OH:16])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][CH:12]([CH3:15])[CH2:13][CH3:14])=[CH:7][CH:6]=1.[H-].[Na+].[Na].Br[C:21]1[S:22][CH:23]=[CH:24][N:25]=1>>[CH3:1][CH:2]([O:16][C:21]1[S:22][CH:23]=[CH:24][N:25]=1)[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][CH:12]([CH3:15])[CH2:13][CH3:14])=[CH:7][CH:6]=1

Participants

5

Reactant 4

HCID 24758Sodium hydrideHCID 764302-BromothiazoleHCID 5360545SodiumHCID 15239106HCID 15239106, compound

Product 1

HCID 15239111HCID 15239111, compound

Procedure

Following the procedure of Example 6, 1-methyl-2-[4-(1-methylpropylthio)phenoxy]ethanol (1.60 g, 6.7 mmol) is treated with sodium hydride (0.48 g, 10.0 mmol), and the resulting sodium salt is reacted with 2-bromo-1,3-thiazole (800 1, 8.7 mmol) to give 2-{1-methyl-2-[4-(1-methylpropylthio)phenoxy]ethoxy}-1,3-thiazole.

Sources & evidence

ORD record
ord-bee390d92ffe44a7a9417e0aba71937c
Source dataset
uspto-grants-1995_02
Patent number
US05389651

Reaction notes

Loading…