反应详情

A solution of methyl 3-methyl-2-nitrobenzoate (1.5 g) and N,N-dimethylacetamide dimethyl acetal (3 ml) in dimethylacetamide (5 ml) was heated at 140° C. for 3 hours. After evaporation of the solvent, the resulting brown syrup was dissolved in ethyl acetate. The solution was washed with water, dried and concentrated to dryness. The residue was purified by column chromatography on silica gel to give a pale brown syrup (0.42 g, 23%).

1. customAfter evaporation of the solvent
2. dissolutionthe resulting brown syrup was dissolved in ethyl acetate
3. washThe solution was washed with water
4. customdried
5. concentrationconcentrated to dryness
6. customThe residue was purified by column chromatography on silica gel