反应详情

50 ml of a 1-molar solution of 4-(2-aminoethyl)-benzoic acid-sodium, which contained, in addition, 0.05 mole of sodium acetate and which had been prepared by saponification of 4-(2-acetylaminoethyl)-benzoic acid with sodium hydroxide solution, was combined with 50 ml of acetone and then with the solution of 9 g of 3-chlorobenzyl chloride in a small amount of acetone. The whole was stirred for about 1 hour, water and hydrochloric acid were added, filtered off with suction and the product was recrystallized from a mixture of water and isopropanol. The 4-(2-<3-chloro-benzamido>-ethyl)-benzoic acid obtained was found to melt at 200° to 202° C.

1. filtrationfiltered off with suction
2. customthe product was recrystallized from a mixture of water and isopropanol