Lithium hydroxide, monohydrate → HCID 178441519, compound

HRID 274619Notes

Reaction equation

HRID 274619 reaction equation
C[O:2][C:3]([C:5]1[S:34][C:8]2[N:9]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[C:29]4[NH:33][N:32]=[N:31][N:30]=4)=[CH:19][CH:18]=3)[C:10]([CH2:12][CH2:13][CH2:14][CH3:15])=[N:11][C:7]=2[CH:6]=1)=[O:4].O.[OH-].[Li+]>C1COCC1.O>[CH2:12]([C:10]1[N:9]([CH2:16][C:17]2[CH:18]=[CH:19][C:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[C:29]3[NH:30][N:31]=[N:32][N:33]=3)=[CH:21][CH:22]=2)[C:8]2[S:34][C:5]([C:3]([OH:4])=[O:2])=[CH:6][C:7]=2[N:11]=1)[CH2:13][CH2:14][CH3:15]

Participants

4

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 178441518HCID 178441518, compound

Product 1

HCID 178441519HCID 178441519, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

2-butyl-3-[(2'-{1H-tetrazol-5-yl}{1,1'-biphenyl}-4-yl)methyl]-3H-thieno[2,3-d]-imidazole-5-carboxylic acid methyl ester (1, A-B-C are --CH=C(CO2CH3)--S--; R6 -E=butyl; R1 =tetrazol-5-yl) prepared as described in Example 5 can be saponified with lithium hydroxide hydrate in THF/H2O (5:1) at room temperature for 24 hours to give the title compound.

Sources & evidence

ORD record
ord-8fb30e818fa3455e8b4dd0680330dd92
Source dataset
uspto-grants-1995_02
Patent number
US05389660

Reaction notes

Loading…