反应详情

To a solution of 20 g (171 mmol) of 2,4-thiazolidinedione and 17.4 ml (171 mmol) of 4-chlorobenzaldehyde in 350 ml of ethanol, 1.68 ml (17.1 mmol) of piperidine was added, and the mixture was heated under reflux for 5 hours. After cooling, the precipitated crystals were filtered and washed with cooled ethanol to give 17.75 g of the desired compound (43.4% yield, pale yellow crystals).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 5 hours
3. temperatureAfter cooling
4. filtrationthe precipitated crystals were filtered
5. washwashed with cooled ethanol