HCID 178440675, compound → 1,2,3,4-Tetrahydroacridine

HRID 274872Notes

Reaction equation

HRID 274872 reaction equation
CC([C:5]1[CH:18]=[C:17]2[C:8]([N:9]=[C:10]3[C:15](=[C:16]2O)[CH2:14][CH2:13][CH2:12][CH2:11]3)=[CH:7][CH:6]=1)(C)C>O=P(Cl)(Cl)Cl>[CH2:14]1[C:15]2[C:10](=[N:9][C:8]3[C:17]([CH:16]=2)=[CH:18][CH:5]=[CH:6][CH:7]=3)[CH2:11][CH2:12][CH2:13]1

Participants

3

Reactant 1

HCID 178440675HCID 178440675, compound

Product 1

HCID 1553151,2,3,4-Tetrahydroacridine

Reagents, catalysts & solvents 1

HCID 24813Phosphorus oxychlorideSolvent

Procedure

7-(1,1-Dimethylethyl)-9-hydroxy-1,2,3,4-tetrahydroacridine (9.46 g) was refluxed for 30 minutes in 50 ml of POCl3. The volatiles were evaporated and the residue was distributed between aqueous NH3 and Et2O. Concentration of the organic phase gave 8.24 g of 9-chloro-7-1,1-dimethylethyl)-1,2,3,4-tetrahydroacridine.

Workup

  1. customThe volatiles were evaporated

Sources & evidence

ORD record
ord-d49da7c79046488e9d1316a16e270795
Source dataset
uspto-grants-1995_02
Patent number
US05391553

Reaction notes

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