反应详情

1.4 g (7 mmol) of methyl 6-(N,N-dimethylamino)-3-hydroxypicolinate, 1.6 g (7 mmol) of 4,6-dimethoxy-2-methylsulfonylpyrimidine and 0.6 g (4 mmol) of potassium carbonate were added to 100 ml of dimethylformamide (DMF), and were reacted at 90° C. for 2 hours. After the reaction, the reaction content was poured into water, and was extracted with diethyl ether, and then washed with water, dried and concentrated to obtain an oily product which was thereafter crystallized with isopropyl ether. The crystal thus obtained was recrystallized with ethyl acetate/n-hexane to obtain an aimed product.

1. customwere reacted at 90° C. for 2 hours
2. customAfter the reaction
3. extractionwas extracted with diethyl ether
4. washwashed with water
5. customdried
6. concentrationconcentrated
7. customto obtain an oily product which
8. customwas thereafter crystallized with isopropyl ether
9. customThe crystal thus obtained
10. customwas recrystallized with ethyl acetate/n-hexane