反应详情

LAH pellets (3.2 g, 84.3 mmole) were added slowly to a stirred solution of 3,4-dihydro-2H-1-benzopyran-2-carboxylic acid (15 g, 84.3 mmole) in THF (150 ml). After the vigorous reaction subsided, the mixture was refluxed for 1 hr and then cooled. To the hot mixture were added sequentially, H2O (3.2 ml), 15% NaOH (3.2 ml), and then H2O (12.8 ml). The mixture was filtered and the filter cake washed with THF. The THF filtrate was concentrated in vacuo, and Kugelrohr distilled to a clear oil (13.85 g, 100%). This alcohol intermediate was stirred in SOCl2 for 18 hr. The excess SOCl2 was removed in vacuo and the resulting dark oil was Kugelrohr distilled to a clear oil (8.65 g, 56.2%). This alkyl chloride intermediate was heated to 100° in DMF with NaN3 (4.32 g, 66 mmole) and KI (0.2 g) for 72 hr. The mixture was diluted with H2O (250 ml) and extracted with CH2Cl2 three times. The CH2Cl2 extracts were concentrated in vacuo. The residue was hydrogenated at 60 psi over 10% Pd/C (1 g) in ethanol and 37% HCl (10 ml) for 3 hr. H2O (20 ml) was added and the mixture was filtered. The ethanol was removed in vacuo and the aqueous residue was made basic with 10 N NaOH. The mixture was extracted three times with ethyl acetate (50 ml portions). The extracts were concentrated in vacuo and the tan oil was Kugelrohr distilled to a dear oil (6.35 g, 82.2%). The product was used without further purification.

1. customAfter the vigorous reaction
2. temperaturethe mixture was refluxed for 1 hr
3. temperaturecooled
4. additionTo the hot mixture were added sequentially
5. filtrationThe mixture was filtered
6. washthe filter cake washed with THF
7. concentrationThe THF filtrate was concentrated in vacuo, and Kugelrohr
8. distillationdistilled to a clear oil (13.85 g, 100%)
9. customThe excess SOCl2 was removed in vacuo
10. distillationdistilled to a clear oil (8.65 g, 56.2%)
11. extractionextracted with CH2Cl2 three times
12. concentrationThe CH2Cl2 extracts were concentrated in vacuo
13. waitThe residue was hydrogenated at 60 psi over 10% Pd/C (1 g) in ethanol and 37% HCl (10 ml) for 3 hr
14. additionH2O (20 ml) was added
15. filtrationthe mixture was filtered
16. customThe ethanol was removed in vacuo
17. extractionThe mixture was extracted three times with ethyl acetate (50 ml portions)
18. concentrationThe extracts were concentrated in vacuo
19. distillationdistilled to a dear oil (6.35 g, 82.2%)
20. customThe product was used without further purification