Hydrochloric Acid → HCID 178428635, compound

HRID 274963Notes

Reaction equation

HRID 274963 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH:11]([NH:21][S:22]([C:25]3[CH:26]=[CH:27][C:28]4[N:29]([CH2:38][C:39]([O:41]CC)=[O:40])[C:30]5[C:35]([C:36]=4[CH:37]=3)=[CH:34][CH:33]=[CH:32][CH:31]=5)(=[O:24])=[O:23])[C:12]([N:14]3[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]3)=[O:13])=[CH:9][C:4]=2[N:3]=[CH:2]1.[OH-].[Na+].Cl>O1CCOCC1.CO.O>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH:11]([NH:21][S:22]([C:25]3[CH:26]=[CH:27][C:28]4[N:29]([CH2:38][C:39]([OH:41])=[O:40])[C:30]5[C:35]([C:36]=4[CH:37]=3)=[CH:34][CH:33]=[CH:32][CH:31]=5)(=[O:24])=[O:23])[C:12]([N:14]3[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]3)=[O:13])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178472584HCID 178472584, compound

Product 1

HCID 178428635HCID 178428635, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
20 °C

Procedure

To a solution of 0.6 g (0.001 Mol) of ethyl [3-[[1-(1H-benzimidazol-5-yl-methyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]sulphamoyl]-carbazol-9-yl]-acetate in 5 ml of dioxane and 5 ml of methanol are added dropwise 4 ml of 1N sodium hydroxide solution and the mixture is stirred at 20° C. for one hour. It is then diluted with 20 ml of water and mixed with 4 ml of 1N hydrochloric acid. The organic solvent is eliminated in vacuo, the product precipitated is suction filtered, washed with water and dried.

Workup

  1. customthe product precipitated
  2. filtrationfiltered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-e77be60f7eda4e12a6f172fa08f2298c
Source dataset
uspto-grants-1995_02
Patent number
US05391556

Reaction notes

Loading…