反应详情

温度

70 °C

To a stirring solution of 10.0 g (91 mmol) of thiophenol in 170 mL of DMF is added 6.2 g (95 mmol) of KOH. When the KOH has dissolved, 17 g (91 mmol) of 2,5-dichloronitrobenzene is added. After stirring for 3 hours at 70° C. the solvent is removed in vacuo. The residue is partitioned between CHCl3 and N NaOH. The organic layer is washed with N NaOH, H2O, N HCl, H2O and is dried over NaSO4 anhydrous, filtered, and stripped. The product is crystallized from cyclohexane.

1. customis removed in vacuo
2. customThe residue is partitioned between CHCl3 and N NaOH
3. washThe organic layer is washed with N NaOH, H2O, N HCl, H2O
4. dry with materialis dried over NaSO4 anhydrous
5. filtrationfiltered
6. customThe product is crystallized from cyclohexane