Phosphorus oxychloride → 2-Chloro-1,7-bis(phenylmethyl)purin-6-one

HRID 275340Notes

Reaction equation

HRID 275340 reaction equation
[C:1]1([CH2:7][N:8]2[C:16](=[O:17])[C:15]3[N:14]([CH2:18][C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:13]=[N:12][C:11]=3[NH:10][C:9]2=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O=P(Cl)(Cl)[Cl:28]>>[Cl:28][C:9]1[N:8]([CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:16](=[O:17])[C:15]2[N:14]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:13]=[N:12][C:11]=2[N:10]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 109145511H-Purine-2,6-dione, 3,7-dihydro-1,7-bis(phenylmethyl)-

Product 1

HCID 200878862-Chloro-1,7-bis(phenylmethyl)purin-6-one

Procedure

Treat 1,7-bis(phenylmethyl)purin-2,6-dione with POCl3 in accordance with Preparative Example 4, to give the title compound, an off-white solid, EI MS: M+=350.

Sources & evidence

ORD record
ord-970a631596fa446fa9adce628d74887a
Source dataset
uspto-grants-1995_02
Patent number
US05393755

Reaction notes

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