反应详情

A mixture of 54 g of 1-(4-fluorophenyl)ethanone, 39.1 g of dimethylamine hydrochloride, 14.4 g of paraformaldehyde, and 10 ml of 36% hydrochloric acid was refluxed for 2 h in 500 ml of ethanol. The ethanol was evaporated and ethyl acetate was added, after which 79 g (82%) of 1-(4-fluorophenyl)-3-(dimethylamino)-propanone hydrochloride was obtained.

1. customThe ethanol was evaporated
2. additionethyl acetate was added