反应详情

A mixture of 4-[2-(benzylamino)ethoxy]phenylacetamide (OLS 2135678) (14.0 g), (R)-styrene oxide (5.92 g) and propan-2-ol (200 ml) was heated under reflux for 72 hours. The mixture was cooled and the solvent evaporated under reduced pressure. The residue was purified by dry, flash column chromatography. Elution with 10% methanol in dichloromethane gave (R)-4-[2-(N-benzyl-N-(2-hydroxy-2-phenylethyl)amino)ethoxy]phenylacetamide as an oil (12.9 g). This reaction may also be performed in t-amyl alcohol under reflux.

1. temperaturewas heated
2. temperatureunder reflux for 72 hours
3. temperatureThe mixture was cooled
4. customthe solvent evaporated under reduced pressure
5. customThe residue was purified
6. customby dry
7. washElution with 10% methanol in dichloromethane