Hydrochloric Acid → HCID 22848439, compound

HRID 275585Notes

Reaction equation

HRID 275585 reaction equation
C(O)(=O)C.[C:5]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][NH:15][C:16](=[O:50])[CH2:17][C@H:18]([NH:36][S:37]([C:40]2[CH:49]=[CH:48][C:47]3[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=3)[CH:41]=2)(=[O:39])=[O:38])[C:19](=[O:35])[N:20]2[CH2:25][CH2:24][O:23][CH:22]([CH2:26][O:27]CC3C=CC=CC=3)[CH2:21]2)[CH2:9]1)(=[NH:7])[NH2:6].[ClH:51]>C(O)C.[Pd]>[ClH:51].[C:5]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][NH:15][C:16](=[O:50])[CH2:17][C@H:18]([NH:36][S:37]([C:40]2[CH:49]=[CH:48][C:47]3[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=3)[CH:41]=2)(=[O:39])=[O:38])[C:19](=[O:35])[N:20]2[CH2:25][CH2:24][O:23][CH:22]([CH2:26][OH:27])[CH2:21]2)[CH2:9]1)(=[NH:6])[NH2:7]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22848437HCID 22848437, compound

Product 1

HCID 22848439HCID 22848439, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of the product from Example 54 in ethanol/IN hydrochloric acid is hydrogenated in the presence of 10% Pd/C for 30 hours under normal conditions. There is obtained (βS,2RS)-N-[[(RS)-1-amidino-3-piperidinyl]methyl]-2-hydroxymethyl-β-2-naphthylsulfonamido-γ-oxo-4-morpholinebutyramide hydrochloride, FAB-MS: 561 (M+H)+.

Sources & evidence

ORD record
ord-a446878717f74e1b8b0bcc658b08f883
Source dataset
uspto-grants-1995_02
Patent number
US05393760

Reaction notes

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