反应详情

A solution of 3,5-dibromo-4-amino-pyridine 1 (4.0 g, 15.87 mmol), Pd(PPh3)4 (0.91 g, 0.78 mmol) and aqueous solution of Na2CO3 (23.8 ml, 2M ) in toluene (80 ml ) is added to a solution of dichlorobenzene boronic acid (6.23 g, 46.4 mmole) in ethanol (24 ml). The mixture is refluxed for 14 h., diluted with ethyl acetate and washed with saturated NH4Cl solution. The organic layer is dried over sodium sulfate and concentrated in vacuo. The residue is chromatographed on silica gel to give 2.

1. temperatureThe mixture is refluxed for 14 h.
2. washwashed with saturated NH4Cl solution
3. dry with materialThe organic layer is dried over sodium sulfate
4. concentrationconcentrated in vacuo
5. customThe residue is chromatographed on silica gel
6. customto give 2