反应详情

A mixture of the product from the previous reaction (0.25 g), potassium carbonate (2 g) and 1-[1-(2-methoxyphenyl)piperid-4-yl]methylamine (0.3 g) in a mixture of dimethylformamide (5 ml) and toluene (10 ml) was heated at reflux temperature for 8 hours. The cooled mixture was poured into water (100 ml) and extracted with ethyl ether (2×100 ml). The combined extracts were then dried over magnesium sulphate and the solvent removed under reduced pressure to yield a yellow oil. Purification by flash column chromatography on silica eluting with a 20:1 mixture of dichloromethane and methanol afforded (S)-N-(2,3-dihydro-7H-1,4-dioxino[2,3-e]indazol-2-ylmethyl)-1-[1-(2-methoxyphenyl)piperid-4-yl]methylamine (0.04 g) as a gummy solid.

1. additionA mixture of the product
2. temperaturewas heated
3. temperatureat reflux temperature for 8 hours
4. extractionextracted with ethyl ether (2×100 ml)
5. dry with materialThe combined extracts were then dried over magnesium sulphate
6. customthe solvent removed under reduced pressure
7. customto yield a yellow oil
8. customPurification by flash column chromatography on silica eluting
9. additionwith a 20:1 mixture of dichloromethane and methanol