反应详情

To a solution of 4-methoxy-2-trifluoromethylbenzimidazole (1.4 g) in tetrahydrofuran (40 ml) under nitrogen was added sodium hydride (0.32 g; 60% dispersion in oil). The mixture was stirred for 20 minutes at room temperature before methyl iodide (1.35 g) was added. Stirring was continued overnight. The reaction was quenched by the addition of water (10 ml) and the solvent removed in vacuo. Ethyl acetate (50 ml) was added and the organic layer washed with saturated sodium bicarbonate solution (20 ml), water (20 ml) and brine (20 ml). Drying over anhydrous magnesium sulfate followed by the removal of the solvent in vacuo gave the title compound (1.6 g) as an oil which solidified on standing.

1. additionwas added
2. customThe reaction was quenched by the addition of water (10 ml)
3. customthe solvent removed in vacuo
4. additionEthyl acetate (50 ml) was added
5. washthe organic layer washed with saturated sodium bicarbonate solution (20 ml), water (20 ml) and brine (20 ml)
6. dry with materialDrying over anhydrous magnesium sulfate
7. customfollowed by the removal of the solvent in vacuo