反应详情

Potassium carbonate (3.5 g, 25.5 mol) and iodomethane(2.0 ml, 31.9 mmol) was added to a solution of N-(4-hydroxyphenylethyl)acetamide (4.4 g, 24.6 mmol) in ethanol(2.4 ml), which was then refluxed for 12 hours. The resulting solid was filtered and washed with ethanol. The filtrate was concentrated to give oily residue, which was diluted with ethyl acetate and washed with water. The separated organic layer was concentrated and the resulting solid was suspended in ethylether, filtered, and dried to give 2.9 g of the titled compound.

1. temperaturewas then refluxed for 12 hours
2. filtrationThe resulting solid was filtered
3. washwashed with ethanol
4. concentrationThe filtrate was concentrated
5. customto give oily residue, which
6. washwashed with water
7. concentrationThe separated organic layer was concentrated
8. filtrationfiltered
9. customdried