1,2,3,4-Tetrahydroisoquinoline → HCID 18315702, compound

HRID 275927Notes

Reaction equation

HRID 275927 reaction equation
[CH3:1][C:2]1[C:3]([Cl:16])=[N:4][C:5]([NH:9][C:10]2[S:11][CH:12]=[C:13]([CH3:15])[N:14]=2)=[N:6][C:7]=1[CH3:8].[CH2:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20][CH2:19][NH:18]1>CN(C)C=O>[ClH:16].[CH3:1][C:2]1[C:3]([N:18]2[CH2:19][CH2:20][C:21]3[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:17]2)=[N:4][C:5]([NH:9][C:10]2[S:11][CH:12]=[C:13]([CH3:15])[N:14]=2)=[N:6][C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 183156854-Chloro-5,6-dimethyl-N-(4-methyl-2-thiazolyl)-2-pyrimidinamine

Product 1

HCID 18315702HCID 18315702, compoundYield 10.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The same procedures as in Step 4 of Example 22 were repeated using 5,6-dimethyl-2-(4-methylthiazol-2-yl)amino-4-chloropyrimidine(0.85 g, 3.34 mmol), 1,2,3,4-tetrahydroisoquinoline(0.42 ml, 3.34 mmol) and dimethylformamide (5 ml) to afford 140 mg of the titled compound.

Sources & evidence

ORD record
ord-00eae21235944d0ca312a6bf37e89a46
Source dataset
uspto-grants-2002_03
Patent number
US06352993B1

Reaction notes

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