Triethylamine → 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide

HRID 275965Notes

Reaction equation

O[N:2]1[C:6]2[CH:7]=CC=CC=2N=N1.[CH2:11]([N:18]1[CH2:23]CN(CC(O)=O)C[CH2:19]1)[C:12]1[CH:17]=CC=CC=1.[CH2:28]([N:30](CC)CC)C>>[CH2:6]([N:2]=[C:28]=[N:30][CH2:17][CH2:12][CH2:11][N:18]([CH3:19])[CH3:23])[CH3:7]

Participants

Reactant 3

HCID 8471Triethylamine

HCID 757711-Hydroxybenzotriazole

HCID 1402890(4-Benzyl-piperazin-1-yl)-acetic acid

Product 1

HCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide

Procedure

The same procudures as in Example 167 were repeated using 5,6-dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-6-hydroxy 1,2,3,4-tetrahydroisoquinolin-2-ylppyrimidine(50 mg, 0.132 mmol ), 1-hydroxybenzotriazole(26.8 mg, 0.1 98 mmol), -ethyl-3-(3-dimethylaminopropyl)carbodiimide(32.9 mg, 0.171 mol), 4-benzylpiperazinoacetic acid dihydrochyoride (48.7 mg, 0.158mmol), and triethylamine(64 μl, 0.462mmol) to afford the titled compound.

Sources & evidence

ORD record: ord-e3c9ec45a057484b98a0599544efec61
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06352993B1

Reaction notes

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