Ethyl bromoacetate → HCID 18316767, compound

HRID 275981Notes

Reaction equation

HRID 275981 reaction equation
Br.[Br:2][CH2:3][CH2:4][C:5]1[CH:11]=[CH:10][C:8]([NH2:9])=[CH:7][CH:6]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>CN(C)C=O>[Br:2][CH2:3][CH2:4][C:5]1[CH:11]=[CH:10][C:8]([NH:9][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 18316762HCID 18316762, compound

Product 1

HCID 18316767HCID 18316767, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4-(2-bromoethyl)aniline hydrobromide (9.15 g) in N,N-dimethylformamide (65 ml) were added potassium carbonate (4.95 g) and ethyl bromoacetate (3.97 ml), and the mixture was stirred for 36 hours at room temperature. The reaction mixture was poured into ice-water, and collection of the resulting precipitates by filtration gave ethyl N-[4-(2-bromoethyl)phenyl]aminoacetate (8.39 g)

Workup

  1. customprecipitates by filtration

Sources & evidence

ORD record
ord-087c87c3a38a4d92a16aaded4ddc1558
Source dataset
uspto-grants-2002_03
Patent number
US06353025B1

Reaction notes

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