反应详情

To 0.500 g of 1-(2-chlorobenzyl)-2-methylbenzimidazole-6-acetonitrile was added 10% hydrochloric acid, and the mixture was heat-refluxed for 15 hours. The reaction mixture was neutralized with a saturated aqueous solution of sodium hydrogencarbonate, and was extracted with chloroform. The organic layer was concentrated, and was purified through silica-gel column chromatography (eluent: a mixture of chloroform and methanol at a ratio of 9:1 to 4:1) to give 0.170 g of 1-(2-chlorobenzyl)-2-methylbenzimidazole-6-acetic acid (160).

1. temperaturethe mixture was heat-refluxed for 15 hours
2. extractionwas extracted with chloroform
3. concentrationThe organic layer was concentrated
4. customwas purified through silica-gel column chromatography (eluent
5. additiona mixture of chloroform and methanol at a ratio of 9:1 to 4:1)