反应详情

Oxalyl chloride (0.437 g) was added to a solution of 0.490 g of 6-carboxy-1-(2,4-dichlorobenzyl)-2-methylbenzimidazole and 1 drop of N,N-dimethylformamide in 8 ml of methylene chloride while being cooled with ice, and the mixture was stirred at room temperature for 1.5 hours. Four milliliters of 28% aqueous ammonia were added thereto, and the solution was stirred at room temperature for 12 hours. The reaction solution was extracted with the addition of water and methylene chloride. The organic layer was concentrated, and the crystals precipitated were then collected, and were dried to give 0.240 g of 6-carbamoyl-1-(2,4-dichlorobenzyl)-2-methylbenzimidazole (223).

1. temperaturewhile being cooled with ice
2. stirringthe solution was stirred at room temperature for 12 hours
3. extractionThe reaction solution was extracted with the addition of water and methylene chloride
4. concentrationThe organic layer was concentrated
5. customthe crystals precipitated
6. customwere then collected
7. customwere dried