反应详情

温度

80 °C

A mixture of 1.61 g of 4-ethoxycarbonyl-2-methylbenzimidazole, 3.08 g of 2,4-dichlorobenzyl chloride, 1.51 g of potassium iodide, 1.05 g of potassium carbonate and 4 ml of N,N-dimethylformamide was stirred at 80° C. for 16 hours. The reaction mixture was extracted with chloroform and with water. The chloroform layer was washed with water, dried, and concentrated. The residue was purified through silica-gel column chromatography (eluent: a mixture of hexane and ethyl acetate at a ratio of 2:8) to give 0.730 g of 1-(2,4-dichlorobenzyl)-4-ethoxycarbonyl-2-methylbenzimidazole (297).

1. extractionThe reaction mixture was extracted with chloroform and with water
2. washThe chloroform layer was washed with water
3. customdried
4. concentrationconcentrated
5. customThe residue was purified through silica-gel column chromatography (eluent
6. additiona mixture of hexane and ethyl acetate at a ratio of 2:8)