2-Bromoethanol → HCID 18316808, compound

HRID 276091Notes

Reaction equation

HRID 276091 reaction equation
[CH2:1]([NH:8][C:9]1[CH:10]=[C:11]([OH:15])[CH:12]=[CH:13][CH:14]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].Br[CH2:17][CH2:18][OH:19].C([O-])(O)=O.[Na+]>CO>[CH2:1]([N:8]([C:9]1[CH:10]=[C:11]([OH:15])[CH:12]=[CH:13][CH:14]=1)[CH2:17][CH2:18][OH:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

5

Reactant 3

HCID 108982-BromoethanolHCID 516892Sodium BicarbonateHCID 18316812HCID 18316812, compound

Product 1

HCID 18316808HCID 18316808, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.1 mol of 3-(n-heptyl-amino)phenol in 100 ml of methanol is refluxed for 10 h with 0.11 mol of 2-bromoethanol and 0.1 mol of NaHCO3. After cooling, the mixture is filtered, the solvent is removed in vacuo and the residue is fractionated, to give 3-[N-(n-heptyl)-N-(2-hydroxyethyl)amino]phenol; b.p. 160-170° C. (1·10 −5 torr), m.p. 45-47° C., yld. 54%.

Workup

  1. temperatureAfter cooling
  2. filtrationthe mixture is filtered
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-ad5eced58fd5474085c0a9ca5e9a15bd
Source dataset
uspto-grants-2002_03
Patent number
US06353059B2

Reaction notes

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