1-Butanol → HCID 86757831, compound

HRID 276100Notes

Reaction equation

HRID 276100 reaction equation
[N:1]([C@@H:4]1[C@H:13]([O:14]C(=O)C)[C@@H:12]([O:18]C(=O)C)[C@H:11]([CH2:22][O:23]C(=O)C)[O:10][C@@H:5]1[O:6]C(=O)C)=[N+:2]=[N-:3].C(O)CCC>Cl>[N:1]([C@@H:4]1[C@H:13]([OH:14])[C@@H:12]([OH:18])[C@H:11]([CH2:22][OH:23])[O:10][CH:5]1[OH:6])=[N+:2]=[N-:3]

Participants

4

Reactant 2

HCID 2631-ButanolHCID 86757832HCID 86757832, compound

Product 1

HCID 86757831HCID 86757831, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of Compound 9 (541 mg, 1.45 mmol) in 3N aqueous hydrochloric acid (100 mL) was warmed until solution became clear and then stirred at room temperature. After 10 hours, n-butanol was added and the solution was evaporated. The residue was chromatographed on a flash column with CHCl3—MeOH (4:1) to give 0.244 g of Compound 9a in 82 percent yield.

Workup

  1. customthe solution was evaporated
  2. customThe residue was chromatographed on a flash column with CHCl3—MeOH (4:1)

Sources & evidence

ORD record
ord-2d0c18a930c7489b9646d69b948fc179
Source dataset
uspto-grants-2002_03
Patent number
US06353095B1

Reaction notes

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