反应详情

Combine 2-(4-methoxybenzylthio)-pentanoyl-(L)-homophenylalanyl-(L)-phenylalanine t-butyl ester (0.20 g, 0.33 mmol), mercury (II) acetate (0.134 g, 0.42 mmol), and anisole (0.37 mL, 3.4 mmol) in dichloromethane (9 mL). Cool in an ice bath and degas by repeatedly applying vacuum and filling the vessel with nitrogen, Add trifluoroacetic acid (4 mL). After 1 hour, warm to ambient temperature. After 3 hours, purge with hydrogen sulfide (gas) for about 10 minutes. Filter and evaporate in vacuo to give a residue. Repeatedly, combine the residue and carbon tetrachloride and evaporate in vacuo to give a residue. Triturate the residue with hexane to give the title compound as a solid (85 mg, 57%).

1. temperatureCool in an ice bath
2. customdegas
3. additionAdd trifluoroacetic acid (4 mL)
4. waitAfter 3 hours
5. custompurge with hydrogen sulfide (gas) for about 10 minutes
6. filtrationFilter
7. customevaporate in vacuo
8. customto give a residue
9. customevaporate in vacuo
10. customto give a residue
11. customTriturate the residue with hexane