Hydrochloric Acid → HCID 53683895, compound

HRID 276733Notes

Reaction equation

HRID 276733 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:9]=[CH:8][N:7]([CH2:10][CH2:11][CH2:12][C@H:13]([NH:21]C(OC(C)(C)C)=O)[C:14]([O:16]C(C)(C)C)=[O:15])[N:6]=1)=[O:4].Cl>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[CH:9]=[CH:8][N:7]([CH2:10][CH2:11][CH2:12][C@H:13]([NH2:21])[C:14]([OH:16])=[O:15])[N:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54106428HCID 54106428, compound

Product 1

HCID 53683895HCID 53683895, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of t-butyl (S)-5-(3-methoxycarbonyl-1H-pyrazol-1-yl)-2-(t-butoxycarbonylamino)-pentanoate (0.84 g, 0.21 mmol) in CH2Cl2 (20 mL) at 0° C. is bubbled HCl gas for 30 minutes. Afterward, the solution is warmed to room temperature over 30 minutes. Evaporation of solvent yields (S)-5-(-3-methoxycarbonyl-1H-pyrazol-1-yl)-2-aminopentanoic acid.HCl as a gray-white solid.

Workup

  1. customEvaporation of solvent

Sources & evidence

ORD record
ord-63454fb629c943d78b8902eb078ef3bd
Source dataset
uspto-grants-2002_03
Patent number
US06353017B1

Reaction notes

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