反应详情

2-Amino-5-nitropyridine was treated with acetic anhydride in dry pyridine in the presence of 4-dimethylaminopyridine at room temperature for 24 hrs under argon. The solvent was removed by rotary evaporation. The residue was dissolved in CH2Cl2, and ether was added to form a solid. The white solid was collected and dried giving 2-acetamido-5-nitropyridine. Hydrogenation of this material using 10%Pd on C in MeOH at room temperature under atmospheric pressure gave 2-acetamido-5-aminopyridine.

1. customThe solvent was removed by rotary evaporation
2. dissolutionThe residue was dissolved in CH2Cl2
3. additionether was added
4. customto form a solid
5. customThe white solid was collected
6. customdried