反应详情

1-t-Butoxycarbonyl-4-hydroxy-4-phenylpiperidine (300 mg, 1.1 mmol) was dissolved in tetrahydrofuran (9 ml). Thereto was added sodium hydride (43 mg, 1.1 mmol), and the resulting solution was stirred at a room temperature for 1 hour. The reaction solution was mixed with methyl iodide (0.1 ml, 1.6 mmol) and again stirred for 17 hours. The solvent was evaporated under a reduced pressure, and the thus obtained residue was mixed with ethyl acetate and water. The reaction product was extracted with ethyl acetate, washed with water and saturated brine and dried with anhydrous sodium sulfate. Then the compound obtained by the evaporation of the solvent under a reduced pressure was separated and purified by a silica gel column chromatography to obtain 240 mg of the title compound (0.82 mmol, 76% in yield).

1. stirringagain stirred for 17 hours
2. customThe solvent was evaporated under a reduced pressure
3. additionthe thus obtained residue was mixed with ethyl acetate and water
4. extractionThe reaction product was extracted with ethyl acetate
5. washwashed with water and saturated brine
6. dry with materialdried with anhydrous sodium sulfate
7. customThen the compound obtained by the evaporation of the solvent under a reduced pressure
8. customwas separated
9. custompurified by a silica gel column chromatography