反应详情

A mixture of 1-hydroxy-5-oxo-5,6,7,8-tetrahydronaphthalene (10 g), potassium carbonate (9.4 g), methyl bromoacetate (6.2 ml) in acetonitrile (250 ml) was refluxed with stirring for 3.5 hours. The mixture was filtered off and the filtrate was evaporated in vacuo. The residue was partitioned between ethyl acetate and water. The separated organic layer was wasted with 1N-hydrochloric acid, 1N-sodium hydroxide, brine, dried over magnesium sulfate and evaporated in vacuo. The residue was suspended in n-hexane and then the solid was collected by filtration to give 1-methoxycarbonylmethoxy-5-oxo-5,6,7,8-tetrahydronaphthalene (13.90 g).

1. temperaturewas refluxed
2. filtrationThe mixture was filtered off
3. customthe filtrate was evaporated in vacuo
4. customThe residue was partitioned between ethyl acetate and water
5. dry with materialdried over magnesium sulfate
6. customevaporated in vacuo
7. filtrationthe solid was collected by filtration