反应详情

温度

90 °C

A mixture of 30 mg (0.1 mmol) 7-bromo-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine, 15.5 mg (0.11 mmol) p-tolyl-boronic acid, and 0.1 ml aqueous 2M Na2CO3 in 0.5 ml 1,2-dimethoxyethane was treated with 6 mg (0.01 mmol) tetrakis-(triphenylphosphine)-palladium(0) and heated to 90° C. for 15 h. Water was added and the mixture was adjusted to pH=12 with 2M NaOH and extracted with ethylacetate. The organic phases were dried with Na2SO4 and concentrated under reduced pressure yielding 22 mg (71%) 2-phenyl-7-p-tolyl-3H-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine, MS m/e (%): 300 (M+, 100).

1. extractionextracted with ethylacetate
2. dry with materialThe organic phases were dried with Na2SO4
3. concentrationconcentrated under reduced pressure