Pyrazole → 2-Pyrazol-1-yl-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

HRID 277126Notes

Reaction equation

HRID 277126 reaction equation
[N:1]1[CH:2]=[N:3][N:4]2[C:9]([NH2:10])=[CH:8][CH:7]=[CH:6][C:5]=12.N12[CH2:21][CH2:20][CH2:19][N:18]=[C:17]1[CH2:16]CCCC2.[NH:22]1[CH:26]=[CH:25][CH:24]=[N:23]1>>[N:22]1([C:2]2[N:1]=[C:5]3[CH:6]=[C:7]([C:20]4[CH:19]=[N:18][CH:17]=[CH:16][CH:21]=4)[CH:8]=[C:9]([NH2:10])[N:4]3[N:3]=2)[CH:26]=[CH:25][CH:24]=[N:23]1

Participants

4

Reactant 3

HCID 1048PyrazoleHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 22629716[1,2,4]Triazolo[1,5-a]pyridin-5-amine

Product 1

HCID 183136592-Pyrazol-1-yl-7-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

Procedure

The title compound, MS m/e (%):277 (M+,100), was prepared in accordance with the method of example 339b) from 2-methanesulfinyl-7-pyridin-3-yl—([1,2,4]triazolo[1,5-a]pyridin-5-ylamine and 1,8-diazabicyclo[5.4.0]undec-7-en in pyrazole at 75° C.

Sources & evidence

ORD record
ord-10c418fc23f44f2e8a0418326264c03f
Source dataset
uspto-grants-2002_03
Patent number
US06355653B1

Reaction notes

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