Hydrochloric Acid → HCID 11002043, compound

HRID 277307Notes

Reaction equation

HRID 277307 reaction equation
C1C=C2C(C(O)(O)C(=O)C2=CC=1)=O.Cl.CO[C:17]1[CH:41]=[CH:40][C:20]([C:21]([NH:34][CH2:35][CH2:36][NH:37][CH:38]=[O:39])([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:19][CH:18]=1.COC1C=CC(C(NCCNC=O)(C2C=CC=CC=2)C2C=CC(OC)=CC=2)=CC=1>C(Cl)Cl.CO>[C:21]([NH:34][CH2:35][CH2:36][NH:37][CH:38]=[O:39])([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:20]1[CH:19]=[CH:18][CH:17]=[CH:41][CH:40]=1

Participants

6

Reactant 4

HCID 313Hydrochloric Acid3×HCID 10236Ninhydrin3×HCID 54548506HCID 54548506, compoundHCID 86757862HCID 86757862, compound

Product 1

HCID 11002043HCID 11002043, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent3×

Procedure

C22H22N2O (330.42); RF=0.87 (DCM/MeOH 5:1, v/v); spot stains with ninhydrin spray or with HCl vapour); 2-(4-monomethoxytrityl)aminoethylformamide; C23H24N2O2 (360.46); RF=0.86 (DCM/MeOH 5:1, v/v); spot stains with ninhydrin spray or with HCl vapour); 1H NMR (CDCl3, 250.133 MHz):=1.70 (br s, 1 H); 2.32 (tr, 2H, J=6.0 Hz); 3.37 (m, 2H); 3.76 (s, 3H); 5.99 (br s, 1H); 6.78-7.49 (m, 14H); 8.17 (s, 1H). 13C NMR (CDCl3, 62.896 MHz):=38.7 (CH2); 43.1 (CH2); 55.2 (CH3); 70.2 (C); 113.2 (CH); 126.4 (CH); 127.9 (CH); 128.3 (CH); 129.7 (CH); 137.8 (C); 145.9 (C); 158.0 (C); 164.7 (CHO). 2-(4,4′-dimethoxytrityl)aminoethylformamide; C24H26N2O3 (390.49); RF=0.92 (DCM/MeOH 5:1, v/v); spot stains with ninhydrin spray or with HCl).

Sources & evidence

ORD record
ord-9763176e46cc467b8007e639d05005de
Source dataset
uspto-grants-2002_03
Patent number
US06355726B1

Reaction notes

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