反应详情

温度

20 °C

Bis-(hydroxyethyl)amino benzyl malonic acid was prepared conventionally in a flask equipped with a stirrer and reflux condenser by first charging 0.1 mol of malonic acid, 0.1 mol of diethanol amine and 100 cc methanol. The contents were warmed to a temperature of about 20° C. and then 0.1 mol benzaldehyde were added to the flask and the reaction commenced. After refluxing the reaction mixture for 1 hour, the methanol was removed from the reaction mixture by coupling the flask to a vacuum source and heating to a temperature of about 50° C. The residue remaining in the flask then was triturated in acetone and the resulting acid isolated by filtration.

1. customequipped with a stirrer
2. temperaturereflux condenser
3. customthe reaction commenced
4. temperatureAfter refluxing the reaction mixture for 1 hour
5. customthe methanol was removed from the reaction mixture
6. temperatureheating to a temperature of about 50° C
7. customthen was triturated in acetone
8. customthe resulting acid isolated by filtration