Diisopropylethylamine → HCID 18685245, compound

HRID 277765Notes

Reaction equation

HRID 277765 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[C:11](=[O:28])[N:10]2[C:29](OC2C=CC([N+]([O-])=O)=CC=2)=[O:30])[CH:5]=[CH:6][C:7]=1[F:8].Cl.Cl.[NH2:43][CH2:44][CH2:45][CH2:46][N:47]1[CH2:52][CH2:51][C:50]([C:55]2[CH:60]=[CH:59][CH:58]=[CH:57][C:56]=2[C:61]#[N:62])([C:53]#[N:54])[CH2:49][CH2:48]1.C(N(C(C)C)CC)(C)C>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[C:11](=[O:28])[N:10]2[C:29](=[O:30])[NH:43][CH2:44][CH2:45][CH2:46][N:47]2[CH2:48][CH2:49][C:50]([C:53]#[N:54])([C:55]3[CH:60]=[CH:59][CH:58]=[CH:57][C:56]=3[C:61]#[N:62])[CH2:51][CH2:52]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 22625966HCID 22625966, compoundHCID 22625974HCID 22625974, compound

Product 1

HCID 18685245HCID 18685245, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 11 (0.060 g, 0.109 mmol) in 10 ml of CHCl3 was added N-(3-amino)propyl-4-(2-cyanophenyl)-4-cyanopiperidine dihydrochloride (Example 1) and diisopropyl ethylamine (0.057 mL, 0.329 mmol). The resulting solution was stirred for 2 hours and the crude material purified by PCTLC (5% MeOH in CHCl3/2%NH4OH) affording the title compound.

Workup

  1. customthe crude material purified by PCTLC (5% MeOH in CHCl3/2%NH4OH)

Sources & evidence

ORD record
ord-eed295a2ef0c46b1b660b0d20e429d4d
Source dataset
uspto-grants-2002_03
Patent number
US06358959B1

Reaction notes

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