1,1'-Carbonyldiimidazole → HCID 22626840, compound

HRID 277904Notes

Reaction equation

HRID 277904 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:12])[C:7]=1[CH2:8][C:9]([OH:11])=O.C(N1C=CN=C1)(N1C=CN=C1)=O.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([CH:33]([CH2:36][CH2:37][CH3:38])[CH2:34][NH2:35])[CH:30]=[CH:31][CH:32]=1>C1COCC1>[Cl:12][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[CH2:8][C:9]([NH:35][CH2:34][CH:33]([C:29]1[CH:30]=[CH:31][CH:32]=[C:27]([O:26][CH3:25])[CH:28]=1)[CH2:36][CH2:37][CH3:38])=[O:11]

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 22626827HCID 22626827, compoundHCID 22626847HCID 22626847, compound

Product 1

HCID 22626840HCID 22626840, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By working in a way similar to that described in example 4 but using (3,5-dichloro-pyridin-4-yl)-acetic acid (2.06 g, 10 mmoles), carbonyldiimidazole (1.78 g, 11 mmoles), THF (30 ml) and 2-(3-methoxy-phenyl)-pentylamine (1.93 g 10 mmoles), obtained as described in example 17, 3.7 g of the title compound were obtained (yield: 97%), m.p.: 97-98° C.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-f1c6069875c1442cbbf5935e8ad3bf06
Source dataset
uspto-grants-2002_03
Patent number
US06358973B1

Reaction notes

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