Ethyl Acetate → Hydroxy[2-(trifluoromethyl)phenyl]acetic acid

HRID 277925Notes

Reaction equation

HRID 277925 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=[O:6].C[C:14](=[O:18])[O:15]CC>>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]([OH:6])[C:14]([OH:18])=[O:15]

Participants

3

Reactant 2

HCID 8857Ethyl AcetateHCID 123067o-(Trifluoromethyl)benzaldehyde

Product 1

HCID 101657Hydroxy[2-(trifluoromethyl)phenyl]acetic acid

Procedure

The 2-trifluoromethylbenzaldehyde (43.9 g, 252 mmol) was converted to product in a manner substantially analogous to Preparation 59 to yield 39.1 g. (70.5%). EA, MS(FD).

Workup

  1. customto yield 39.1 g

Sources & evidence

ORD record
ord-65cf0ad731c3423dbd4e46de09a5ec40
Source dataset
uspto-grants-2002_03
Patent number
US06358971B1

Reaction notes

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