Ethyl Acetate → 2-Fluoro-6-(trifluoromethyl)mandelic acid

HRID 277927Notes

Reaction equation

[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:3]=1[CH:4]=[O:5].C[C:15](=[O:19])[O:16]CC>>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:11])([F:12])[F:13])[C:3]=1[CH:4]([OH:5])[C:15]([OH:19])=[O:16]

Participants

Reactant 2

HCID 8857Ethyl Acetate

HCID 5219332-Fluoro-6-(trifluoromethyl)benzaldehyde

Product 1

HCID 226267222-Fluoro-6-(trifluoromethyl)mandelic acid

Procedure

The 2-fluoro-6-trifluoromethylbenzaldehyde (48.4 g, 252 mmol) was converted to product in a manner substantially analogous to Preparation 59 to yield 49.7 g. (84%). EA, MS(FD).

Workup

customto yield 49.7 g

Sources & evidence

ORD record: ord-f7eb1ebf36f54f708b829636243b05de
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06358971B1

Reaction notes

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