反应详情

The 2-amino-3-phenyl-6-(carbomethoxy)imidazo-[1,2-a]-pyridine (83.9 g, 0.314 mol), lithium hyroxide monohydrate (65.9 g, 1.57 mol), 1113 ml of THF, and 371 ml of H2O were combined and stirred for 18 hours at RT. The reaction was concentrated in vacuo and the residue taken up in 5 L of H2O. The pH was adjusted to 5 with 5N HCl. The resulting precipitate was filtered and air dried for 72 hours to give 80.5 g of product. (quant. yeild). NMR, MS(FD).

1. concentrationThe reaction was concentrated in vacuo
2. filtrationThe resulting precipitate was filtered
3. customair dried for 72 hours